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Fewer events in the placebo arm of SURMOUNT-1 compared with ONeil, STEP 1 and STEP 8 for total gastrointestinal AEs and nausea AEs suggest that the relative safety of tirzepatide versus liraglutide and semaglutide may be underestimated for these outcomes (see Supplementary Material Table S3)

Medical conditions and medication interactions can interfere with tirzepatides effectiveness