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10.1056/NEJMoa1916038 N Engl J Med

The local increase in GIP stimulates vagal afferent transmission followed by activation of vagal efferents and enteric neurons that release acetylcholine and/or GRP to stimulate GLP-1 release from the distal gut

Step 3: If the PA is approved, that's that and you can access your medication (yay!)

One of the ongoing debates about this entire class of medications is whether the effects are mediated solely by weight loss and mitigation of the inflammatory consequences of energy toxicity (read: too many calories) versus other biological effects of these medications

If you have concerns about the administration process, refer to the instructions that came with the medication or consult with your healthcare provider

SBS, HY, and LA did the statistical analyses