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Although we adjusted for a wide range of baseline clinical and demographic characteristics, the possibility of residual confounding by unmeasured factors, such as lifestyle, frailty, or socioeconomic status, remains
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To minimize treatment interruptions due to adverse reactions, subsequent Phase III clinical trials may adopt a more gradual dose-escalation strategy to reduce the incidence and severity of gastrointestinal discomfort and other adverse events, thereby enhancing patient tolerance and adherence to the medication
[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Kennedy A, Frank RN
doi: 10.1016/j.physbeh.2010.02.029 191 HayesMRSkibickaKPGrillHJ
