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Clinical nutrition ESPEN, 38, 4349

Chichura KS, Elfers CT, Salameh TS, Kamat V, Chepurny OG, McGivney A, et al
Within this specific population, GLP-1 RAs exhibit major reductions in BW, BMI, WC, and SBP

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But in practice, these are fundamentally different compounds with different receptor profiles, different side effect landscapes, and different outcomes for the people who use them
Each generation adds receptors, weight loss, and metabolic benefits, but also adds complexity and reduces the length of available safety data