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Stop tirzepatide and contact your healthcare provider immediately if you experience severe abdominal pain that does not resolve (possible pancreatitis), vision changes, rapid heartbeat, signs of allergic reaction (rash, difficulty breathing, facial swelling), or symptoms of thyroid issues (lump or swelling in the neck, difficulty swallowing, persistent hoarseness)

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[1] [3] This means it activates both the GIP receptor and the GLP-1 receptor simultaneously, making it pharmacologically distinct from traditional GLP-1 agonists