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Diabetes Obes Metab (2021) 23(9):21946

The combination helped preserve muscle strength and leg torque, with the non-exercising group maintaining muscle capacity while the placebo group continued to lose it

While originally approved for type 2 diabetes, it is seeing growing uptake for weight management in 20252026

The authors compared breast cancer incidence among 15,264 women with prior GLP-1 exposure 1 to the same number of women without exposure, with matching for age, BMI, breast density, race, ethnicity, and history of diabetes

Regular follow-up labsfasting glucose, kidney function, and pancreatitis markershelp detect early complications

A total of 175 participants with obesity-related HFpEF were randomly assigned to receive either tirzepatide (2.5 mg15 mg weekly) or a matching placebo