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This has the effect of lowering intraglomerular pressures and reducing single nephron GFR and subsequent proteinuria

Statistical analysis Baseline characteristics of participants were summarized as mean standard deviation (SD) for continuous variables and percentages for categorical variables

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Early data are promising: retatrutide, a leading candidate in this class, produced 24.2% average weight loss at 48 weeks in a Phase 2 trial, exceeding results seen with current medications

They deliver nutrition without requiring large servings

The generic, called liraglutide, is taken daily, unlike Wegovy and Zepbound, which are taken weekly