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The human gastrointestinal system evolved specifically to break down dietary proteins into component amino acids, creating an inherently hostile environment for intact peptide drugs

Research shows that GLP-1 agonists stimulate fluid secretion in the colon and increase intestinal permeability in some patients

Even 4 mg weekly improved fasting glucose, insulin sensitivity, and HbA1c, showing that metabolic benefits can appear before maximum weight-loss effects
[Wadden STEP 3, JAMA 2021] STEP 5 Trial (Nature Medicine 2022) Long-term data: patients maintained an average 15.2% weight loss over 2 years of continuous semaglutide use, with sustained metabolic improvements including reduced HbA1c, blood pressure, and waist circumference

In a statement Thursday, Genentech CMO Levi Garraway called the disease-free survival data unprecedented. April 18 Product: Takedas Entyvio Indication: Crohns disease The FDA on Thursday approved a subcutaneous (SC) form of Takedas Entyvio for maintenance therapy in adults with moderately to severely active Crohns disease (CD) after induction therapy with intravenous Entyvio

Gradual transition or alternative therapy should be considered
