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FIGURE 3 While glp-1(oz112gf) and glp-1(q175null) result in these extreme opposite phenotypes, there are many other alleles of glp-1 , including weak gain-of-function alleles, and partial loss-of-function alleles, which result in milder phenotypes, especially at permissive temperatures ( glp-1(oz264gf) or glp-1(ar202gf) at higher temperatures result in increased proliferation of the mitotic cells and a delay of entry into the differentiation pathway, resulting in a larger than wild-type progenitor zone (Pepper et al., 2003

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