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Description
When we consume certain nutrients, our bodies release GLP-1, which can bind to and activate GLP-1 receptors to provide therapeutic benefits
doi:10.1016/j.ygcen.2018.10.008 160
According to FDA prescribing information, nausea occurs in 1544% of patients depending on the specific agent and dose, with vomiting, diarrhea, constipation, and abdominal pain also frequently reported
doi: 10.3389/fendo.2019.00155 118 MaXLiuZIlyasILittlePJKamatoDSahebkaAet al
Impact of Treatment with GLP1 Receptor Agonists, Liraglutide 3.0 mg and Semaglutide 1.0 mg, While on a Waiting List for Bariatric Surgery
Together, these observations suggest that receptor-level signaling and anti-inflammatory effects alone may be insufficient to produce functional improvement in energy-demanding tissues such as skeletal muscle and brain, where substrate turnover and mitochondrial metabolic throughput are critical determinants of tissue function
