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[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Sun J, et al

Nutrition 66 , 1621 (2019)

Experimental studies have demonstrated that antidiabetic agents, particularly GLP-1RAs (such as liraglutide) and SGLT2is (such as canagliflozin), exert significant cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury in the context of diabetes

What are the challenges

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Second, emerging evidence suggests these drugs may also directly interact with inflammatory and immune pathways involved in autoimmune disease meaning their benefits may go beyond weight loss alone