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Uptake in this population remains low and many older patients do not initiate the therapy after an event

Johnston IM, Nolan JD, Pattni SS, et al

Appetite Regulation Through Brain Signaling When these medications activate GLP-1 receptors in the brain, particularly in the hypothalamus (the bodys main center for hunger regulation), several important effects occur: Reduced hunger signals Increased feelings of satiety (fullness) Decreased food cravings, particularly for high-calorie foods Modulation of the brains reward response to food This neurological impact helps patients make more mindful food choices without the intense hunger that often derails weight management efforts

As off-label use of GLP-1 agonists continues to rise, particularly for weight loss in otherwise healthy individuals, the authors cite the need for additional guidelines and research

GLP-1 acts as a key metabolic regulator, coordinating multiple physiological processes to maintain glucose homeostasis

ICV GLP-1 reduces food intake in rodents, and this effect is blocked with Exendin (39)