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Glucagon-like peptide-1 (GLP-1) is mainly secreted by preproglucagon neurons

In the largest pharmacogenomics GWAS of GLP-1 medications to date (15,237 participants, replicated in the All of Us cohort), researchers identified a missense variant in GLP1R the gene encoding the very receptor that semaglutide and tirzepatide bind that significantly predicts how much weight a person loses on treatment

Glucagon-like peptide-1 (GLP-1) is an incretin known for its anti-obesity effects, and several effective drugs targeting GLP-1 receptors (GLP-1Rs) have recently been developed to treat obesity

Diabetes mellitus, a condition that significantly elevates the incidence and mortality risks associated with cardiovascular diseases, exacerbates the disease...