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Side effects: Semaglutide commonly causes nausea, constipation, and diarrhea, as well as vomiting (which 24 percent of Wegovy patients reported in one study), all side effects that usually go away after a month or two

Injection technique and site selection The compound is administered as a subcutaneous injection, just like standard tirzepatide

But the sky-high demand for GLP-1 meds has created a booming market for compounded tirzepatide and semaglutide, especially since telehealth companies sell these meds for a fraction of the price of their name-brand counterparts

Renal Outcomes: Kidney Injury Risk Tirzepatide may protect renal function chronically, but acute kidney injury can arise from severe vomiting or diarrhea that causes dehydration

What This Means Practically If cardiovascular risk reduction is a priority (especially for someone with existing heart disease), semaglutide has the stronger evidence base right now

Most patients experience dizziness for a few days to two weeks after a dose increase, peaking when your body is adjusting to new GLP-1 and GIP signaling