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Physiologically, it can bind to GLP-1 receptor on pancreatic beta cells through endocrine, activate adenylate cyclase, increase intracellular cAMP levels, promote glycolysis and ATP production, and enhance glucose-stimulated insulin secretion

Extreme sensitivity reactions such as rash, trouble breathing, swelling of the mouth, face, or throat should be reported to your prescriber immediately

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The SPR sensorgrams showed that 15 of the 18 amino acid substitutions accelerated dissociation from the receptor, and thus weakened the binding to FcRn (Fig

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