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Synaptic efficacy in the VTA and NAc is central to drug-induced neuroadaptations, and GLP-1RAs may reverse or attenuate these maladaptive changes by modulating excitatory/inhibitory balance [7,31]

WW clinicians may prescribe these if someone is ineligible for GLP-1 drugs or if these alternatives are more appropriate

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Hypersensitivity reactions to tirzepatide, including anaphylaxis, have been reported in the FDA prescribing information