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But while these drugs can be highly effective at suppressing appetite and accelerating weight loss, they also introduce new challenges that many people dont anticipate

Using goal weight from day one under-doses protein during the period when lean-mass preservation matters most

The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]

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Avoid injecting into areas that are tender, bruised, red, hard, or scarred

If you have not lost at least 5% by this point, it is worth discussing dose adjustment with your provider