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GLP-1R activation also induced a robust reduction in food intake and body weight

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GLP-1 (glucagon-like peptide-1) is a hormone primarily known for its role in regulating blood sugar levels and appetite

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Although the higher dose showed modest within-group weight reduction and improved HbA1c, unexpectedly substantial placebo-associated weight loss limited the observed treatment effect.

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In patients with diabetes mellitus not achieving targets on lifestyle measures, pharmacologic therapy should be considered

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