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Cardiovascular & hematological agents in medicinal chemistry

This is associated with reduced capacity to utilize fatty acids and glucose, and this impairment promotes lipid accumulation within muscle, aggravating IR and muscle dysfunction

GLP-1R may ameliorate these conditions by improving insulin signaling and reducing insulin resistance in the brain

1 Introduction Glucagon-like peptide-1 (GLP-1) belongs to a class of intestinally derived hormones known as incretins ( Initial studies identified the pancreas as the primary site of GLP-1R expression

Its primary physiological role involves stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, which has made GLP-1 receptor agonists valuable therapeutic agents for type 2 diabetes mellitus