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Additionally, it has been shown to enhance symptoms, improve physical fitness, and lower inflammation and body weight in patients with obesity and heart failure with preserved ejection fraction (Kosiborod et al., 2023)

Novel anti-obesity treatments, especially dual and triple incretin-based coagonists, offer significant weight loss comparable to bariatric surgery without invasiveness

Dosing and Administration Currently orally administered semaglutide is approved by the US Food and Drug Administration (FDA), European Medicines Agency, Health Canada, Australia and Japan as an adjunct to diet and exercise to improve glycaemic control in adults with T2DM

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