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Locked by the conserved disulfide bond (C46-C71) with the N-terminal -helix, 1 strand (residues 61 to 77) of GLP-1R ECD also shifted towards ECL1 by 9.3 (measured at the C of E68)

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Am J Physiol Cell Physiol 283 , C446455, doi:10.1152/ajpcell.00261.2001 (2002)

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Korner J, Bessler M, Inabnet W, Taveras C, Holst JJ