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doi: 10.1038/s42255-023-00931-7 55 ZhangQDelessaCTAugustinRBakhtiMColldenGDruckerDJet al

As illustrated in Figure 1 , insulin resistance, adipose tissue inflammation, and impaired incretin signaling converge at the skinjoint axis to amplify IL-23/IL-17driven immune activation and disease progression

This makes pharmacological sense

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