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A content analysis of TikTok videos and comments about weight loss with Ozempic

New injectable GLP-1s are advancing through clinical trials, with CagriSema (cagrilintide/semaglutide) among the most advanced, showing greater weight loss than semaglutide and expected to seek approval in late 2025

Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]

As relatively new classes of diabetes medications, GLP-1RA and SGLT2 agents are available as branded products with no generic equivalents

In addition to the impact on circulating biomarker levels of in patients with diabetic HFpEF, SGLT2i was associated with early improvements in cardiac structure and function in the diabetic HFpEF patients [64, 65]

When those effects are removed, the metabolic rebound is proportionally larger