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A content analysis of TikTok videos and comments about weight loss with Ozempic

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New injectable GLP-1s are advancing through clinical trials, with CagriSema (cagrilintide/semaglutide) among the most advanced, showing greater weight loss than semaglutide and expected to seek approval in late 2025

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Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]

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As relatively new classes of diabetes medications, GLP-1RA and SGLT2 agents are available as branded products with no generic equivalents

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In addition to the impact on circulating biomarker levels of in patients with diabetic HFpEF, SGLT2i was associated with early improvements in cardiac structure and function in the diabetic HFpEF patients [64, 65]

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When those effects are removed, the metabolic rebound is proportionally larger

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