glp-1 and mental health An analysis on the role of glucagon-like peptide-1 receptor agonists in cognitive disorders Semaglutide & Mental Health |
Description
doi: 10.1152/jn.00228.2024
Since GLP-1 medications slow gastric emptying, drinking large amounts of fluid with meals can exacerbate feelings of fullness and nausea
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NICE guidance (NG28) supports the use of incretin therapies alongside insulin in specific contexts and under specialist advice when HbA1c targets are not achieved with insulin therapy alone, particularly in individuals who would benefit from weight loss

Combination therapy is possible under strict medical supervision but carries cardiovascular risks because phentermine raises heart rate and blood pressure while semaglutide alters glucose and heart rate regulation

Evidence suggests benefits on weight and cardiometabolic risk
