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However, no retrospective epidemiological studies can provide definitive answers, and nausea, vomiting and diarrhoea remain the most clinically relevant adverse effects of these drugs, compromising long-term adherence.
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By adding additional indications, such as cardiovascular (CV) risk for Wegovy, and obstructive sleep apnea for Zepbound, they have increased their value proposition and bargaining power with payers
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