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If reactions first appeared or significantly worsened at a specific dose level, discuss the following options with your healthcare provider: extended time at the current dose before escalating further, smaller escalation increments , pre-injection antihistamine protocol, or exploring whether the therapeutic goals can be achieved at a lower dose

Moreover, damaged neurons and neurites in the AD brain, highly insoluble amyloid peptide deposits, and neurofibrillary tangles provide potent stimuli for inflammation [155]