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268 Inflammatory cytokines (e.g., IL-6 and TNF-) upregulate the expression of CYP24A1 in colon cancer cells by activating the NF-B pathway, which in turn leads to abnormal activation of the Wnt/-catenin pathway and promotes disease progression

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When the medication slows gastric emptying, the bolus of food that eventually does pass into the small intestine can be partially fermented and osmotically active, drawing water into the intestinal lumen and triggering loose stools or diarrhea