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Changes in the performance of these proteins have a direct effect on how the drug is absorbed, distributed, metabolized, and eliminated ( Research has shown that variations in the OCT1 gene play a significant role in the varying effectiveness of metformin treatment for individuals with T2DM ( SLC22A1 gene, responsible for OCT1, decreased the absorption of metformin in the liver without impacting the ability of metformin to lower glucose levels in individuals with T2DM (Zhou et al., 2009

The medication works by slowing stomach emptying and signaling fullness to your brain, helping reduce hunger and calorie intake

Wegovy 2.4mg FAQ Dr Earim Chaudry (MBBS), Chief Medical Officer Medically reviewed on 3rd November, 2025

This means food stays in your stomach for longer, which can make you feel heavy and full, often leading to nausea

One small study suggests it may not, but further research is needed before being able to make recommendations based on the information

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Marso SP, Bain SC, Consoli A, et al
