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2020;81:20f13698

Because tirzepatide is such a potent medication, any change in the source or format of the drug must be handled with precision

For instance, studies on magainin analogs have found that peptide drugs with a net charge of + 4 exhibit the strongest membrane-disrupting activity, while higher net charges may trigger different mechanisms (Wang et al

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F.) 3779 (Royal Society of Chemistry, 2015)

Second, we excluded patients with prior suicidal ideation or suicide attempts to reduce confounding, but this prevented us from evaluating whether tirzepatide could reduce suicidality in that high-risk subset
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