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Critically, "Many patients regain two-thirds of their weight when coming off of these medications." These represent "not a quick fix for weight loss" but require "a commitment to regular injections and ongoing monitoring." 4

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By simultaneously addressing hyperglycemia and excess body weight, Tirzepatide offers a more integrated therapeutic strategy for patients struggling with complex metabolic disorders

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it can centrally inhibit bone formation by binding to leptin receptors in the hypothalamus or locally promote bone formation and inhibit bone resorption by binding to receptors expressed on the surface of osteoblasts [100]

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