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GLP-1 administration induces visceral illness in both rodents (Seeley et al., GLP-1R regulation of food reward In addition to being expressed in hypothalamic areas that regulate homeostatic feeding, the GLP-1R is expressed in areas that mediate food reward in both rodents (Merchenthaler et al., GLP-1R action on brown adipose tissue (BAT) thermogenesis In addition to causing changes in feeding, central GLP-1R activation may regulate body weight by increasing brown adipose tissue (BAT) thermogenesis (reviewed in Lockie et al., GLP-1R action on neuroprotection GLP-1R analogs have neuroprotective and anti-inflammatory properties, which may be contributing the beneficial effects on energy metabolism (reviewed in Holscher, Effectiveness of GLP-1R agonists on weight loss in humans Despite not have a complete understanding of the underlying molecular mechanisms, GLP-1R activation clearly has beneficial effects on both energy and glucose metabolism across a number of species