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[5] Furthermore, the thermic effect of proteinthe energy required to digest and metabolize itis higher (approximately 20-30%) than other macronutrients, potentially supporting metabolic health during weight loss

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While these mechanisms can be helpful for diabetes control and weight loss, they can also cause side effects

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In two studies examining the 6-month effects of semaglutide, patients with metabolic dysfunction-associated steatotic liver diseases (MASLD) and showed reduced skeletal muscle steatosis with preservation of muscle mass [86], whereas in patients with MASLD and human immunodeficiency virus, semaglutide led to a 9.3% decrease in psoas muscle volume with no change in muscle fat fraction [87]