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Results At week 4 after discontinuation, compared with the control group, AOM treatment still had weight loss effect (WMD=0.32 kg, 95% CI3.602.97, P=0.85, I2=83%)

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For this study, MALE were defined as acute limb ischemia requiring thrombectomy or major amputation, and MACE were defined as myocardial infarction, stroke, acute ischemic heart disease, and heart failure

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