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13 No RCTs have primarily tested the effects of GLP-1 RAs on HF hard outcomes and/or mortality in patients with HFpEF or HF with reduced ejection fraction (HFrEF)

In the context of triple agonism, the insulin-stimulating effects of GLP-1R and GIPR activation counterbalance the glucagon receptors glucose-raising action

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It is to maintain the stimulus consistently enough that your body has no reason to sacrifice muscle for fuel

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