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Recent clinical trials have shown impressive results, with many individuals, both diabetic and non-diabetic, achieving significant weight reduction

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Specifically, the opening of ATP-sensitive potassium channels reduces the intracellular calcium concentration by inhibiting voltage-dependent calcium channels, thereby preventing the exocytosis of insulin granules (Li et al., 2021

One possible explanation for the drop in GLP-1 in obese people is an increase in plasma non-esterified fatty acids (NEFA), according to Ranganath [115] et al
