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While native GLP-1 contributes to normal glucose regulation, semaglutide produces receptor activation at levels that exceed endogenous postprandial GLP-1 concentrations, generating clinically significant HbA1c reduction and weight loss

Who can benefit from Oral Semaglutide (Wegovy)

Further randomised controlled and pragmatic trials are needed to define their potential benefits/harms, mechanisms of action and where GLP1RAs might fit into existing treatment pathways for uncontrolled asthma

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