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But there are key differences: Tirzepatide has the lowest nausea rate (31%), while Semaglutide (44%) and Retatrutide (43%) are similar

however, it led to a significant decrease in fat mass, consistent with lower plasma leptin levels (Fig

doi: 10.1016/j.diabet.2023.101470

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Lateral ventricle injection of exendin4 results in the activation of lateral parabrachial nucleus neurons which can be blocked by exendin9 (a GLP1 receptor antagonist), suggesting the involvement of the central GLP1 system on energy balance via the parabrachial nucleus (Richard et al., 2014)

With newer advances in neuroscience techniques, we now know that glutamatergic rather than GABAergic neurons (1) are the specific type of neurons necessary for the ability of liraglutide to induce weight loss