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The American Diabetes Association (ADA) and American College of Physicians (ACP) emphasize individualized treatment approaches for glucose-lowering medications, though specific guidance on treatment interruption and resumption is limited

The SURMOUNT program in obesity demonstrated up to 22.5% mean weight reduction at 72 weeks in the highest dose cohort outcomes that exceeded all previously approved anti-obesity agents at the time of approval

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Dose increases should be gradual

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