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Randomized controlled trial of interferon- beta-1a in secondary progressive MS: clinical results

When prescribed medically for example, in adults with confirmed growth hormone deficiency synthetic HGH works by binding to growth hormone receptors throughout the body, stimulating the production of insulin-like growth factor 1 (IGF-1) in the liver

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While randomized trials are revered for their ability to optimize internal validity, they can be limited with respect to external validity

doi:10.1097/smj.0b013e31823c413e