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Even with optimal medication adherence, the underlying disease may advance, requiring treatment intensification

Use of in vitro assays to assess immunogenicity risk of antibody-based biotherapeutics

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Research has also described a distinct potency pattern across its receptor targets: Strong GIP receptor activity (around 8.9 higher than native GIP) Moderate GLP-1 receptor activation (about 0.4 relative potency) Modest glucagon receptor activity (about 0.3 relative potency) This balanced profile provides a framework for studying coordinated metabolic responses rather than isolated single-pathway effects

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Novo did not have an internal triple agonist in the clinic at the time of the deal and required an external asset to avoid ceding the full triple-agonist category to Lilly's Retatrutide lead