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It is the rare, large harm that matters most, not the average week

Prescriptions remain concentrated in institutional settings following 2023 MHLW inclusion of GLP-1s for cardiovascular secondary prevention

In part 1 we looked at Long-term kidney outcomes of semaglutide in ob*sity and cardiovascular disease in the SELECT trial, today well look at Semaglutide in patients with overw*ight or ob*sity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial As I mentioned in part 1, these will be long pieces so I have divided them into a summary, a deep dive, and then an analysis based on my framework for uses of GLP-1 drugs for actual health issues besides Type 2 Diabetes

Consultation costs, lab work, and prescriptions are not included

Conclusions By recruiting participants with shared disease exposures, the TRIUMPH program will assess the safety and efficacy of retatrutide for the treatment of adults with obesity and two of its common complicationsOSA and OA

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