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Activated IRS then stimulates PI3K, which subsequently initiates the phosphorylation and activation of Akt, also known as protein kinase B

Effects gradually diminish during this washout period

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[DOI] [PubMed] [Google Scholar] 2.Kennedy G.C

Medical history was unremarkable until February 2012, when was made her a diagnosis of impaired glucose tolerance (IGT), insulin-resistance (evaluated by hyperinsulinemic euglycemic clamp) and subclinical hypothyroidism