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Here, we present a review of the current literature surrounding the mechanisms of GLP-1 activity on glycogen metabolism, energy expenditure, and the relevant systems that interplay in inducing these states that can potentially explain the decreases in body weight seen in patients taking GLP-1 agonists, with effects summarized in Figure 1 [6]

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Nathanson D, Ullman B, Lfstrm U, et al

2017;97(2):721-766 Studies examine GLP-1's potential role in: Supporting greater ease and comfort in the body 3 Less overthinking about food decisions 4 Improved consistency with healthy habits 5 Greater confidence staying committed to wellness goals 6 Results may vary

Munc131 is required for the sustained release of insulin from pancreatic beta cells

In adult animals, GLP1RAs reach the brain via circumventricular organs, which lack a fully formed bloodbrain barrier (BBB)