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Description
Semaglutide (Ozempic, Wegovy) is a GLP-1 receptor agonist, while Tirzepatide (Mounjaro, Zepbound) binds with both receptors (GLP-1 and GIP) and thus tends to have more effects on weight loss than semaglutide alone
10.1172/JCI116186
Although its anti-inflammatory properties may contribute to OSAS improvement, the complexity of immune regulation raises the possibility of unforeseen immune-related effects
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Activation of GLP-1R markedly reduced the levels of pro-apoptotic Bax and cleaved-caspase3, and increased anti-apoptotic Bcl-2 in IL-1-induced chondrocytes, indicating that GLP-1R may be a potential target for the treatment of OA
There was a steady rise in the use of these drugs in these countries, especially GLP-1R agonists in the U.S., in the periconceptional period
