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Semaglutide: Understanding the Medication Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist (a medication that mimics a natural hormone regulating blood sugar and appetite).

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Studies suggest that in diet-induced insulin-resistant rodents, insulin-mediated skeletal muscle microvascular blood flow is impaired post-short-term high fat feeding, and this occurs before the development of myocyte or whole-body insulin resistance