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In the DURATION-6 trial, the clinical efficacy of once-weekly exenatide was evaluated and compared to that of liraglutide, an FDA-approved GLP-1R agonist79)

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Increased total cholesterol, triglycerides, and lipoproteins like low and very-low-density lipoprotein have a negative impact on insulin sensitivity

demonstrated that liraglutide treatment reduces postprandial levels of GLP-2 and FGF19, which normally act through FXR and TGR5 receptors to regulate bile acid homeostasis and gallbladder tone

Astrocyte-Neuron Metabolic Cooperation Shapes Brain Activity