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In contrast, during the withdrawal phase, GLP-1RAs appear to exert effects through broader circuits involving the lateral septum, hypothalamus, and brainstem nuclei, modulating stress responsivity, negative affect, and somatic symptoms, as evidenced in models of opioid and nicotine withdrawal
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According to the CDC, as of 2021, 38.1 million adults (14.7%) in the United States had diabetes, with the incidence increasing with age
