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Pharmacogenomics of GLP-1 receptor agonists: Focus on pharmacological profile

In the companys latest phase 3 clinical trial, the highest dose of the pill resulted in a 16.6 percent weight loss at 64 weeks compared with a 2.7 percent loss among those who took a placebo

In fact, GLP-1 medications produce some of the largest weight loss results 2 seen with pharmaceutical treatments

In addition to macrophages, human neutrophils and eosinophils have also been shown to express GLP-1R and GLP-1 signaling significantly decreased the expression of eosinophil-surface activation markers along with a decrease in the production of IL-4, IL-8 and IL-13 (39)

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The effects of GLP-1 receptor agonists on cardiovascular system extend beyond their primary role in glycemic control