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How B12 reduces GLP-1 nausea at the molecular level Nausea affects up to 50% of patients taking GLP-1 receptor agonists

Authors Note: The authors recognize the fast-evolving nature of GLP-1 research and trends and will endeavour to ensure the article remains current with emerging GLP-1 RA data.

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See a doctor if nausea is intense, persists for days, or is accompanied by vomiting, dehydration, or weight loss

Like liraglutide, semaglutide incorporates an Aib substitution at the 8th position in place of Ala, which confers resistance to enzymatic degradation by DPP-4