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When semaglutide activates these receptors, it reduces appetite and food cravings by dampening the brain's reward response to eating

Retatrutide is under clinical development and targets GLP-1, GIP, and glucagon receptors making it a triple agonist

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The total study drug exposure was 4,404.3 patient-years in the pooled tirzepatide group and 2,470.7 patient-years in the pooled comparator group, wherein participants were exposed for a median duration of 44 weeks